Endocrine Abstracts

Use of surrogate indices of insulin resistance depends on comparability of the relationship between glucose and insulin concentrations between different groups. It is unknown whether such surrogate estimates are equally applicable in different ethnic groups with marked differences in insulin sensitivity. We compared markers of insulin sensitivity and secretion in 78 (43 European, 19 Afro-Caribbean and 16 South Asian) normoglycaemic women of (median (lower-upper quartile)) 34.7...

Pubertal gynecomastia is associated with an imbalance between estrogen and androgen action on the breast glandular tissue. It is a common condition presenting at 10-12 years and peaking at 13-14 yrs, followed by involution that is usually complete by 17 yrs. Pathologic entities associated with childhood or adolescence gynecomastia are rare.The purpose of this study was to evaluate the bone mineral density (BMD grams/cm2) of children with puber...

We investigated the relationship between gestational diabetes (GDM) and the metabolic syndrome in 368 (185 European (EUR), 103 South Asian (SA) and 80 Afro-Caribbean (AC)) women studied 20.0 (18.2-22.1) months (mean (95% CI)) following a GDM pregnancy and 482 normoglycaemic women (288 EUR, 99 SA, 95 AC) with no history of GDM. Estimates of beta-cell function (%B) and insulin sensitivity (%S) were derived using the HOMA method. Analysis was by multiple linear regression includi...